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Lab Publications

An Optimized Method To Isolate Female Mouse Urethral Epithelium For Single-Cell And Immunofluorescence Analysis

Samtiya M, Rodrigues R, Jasmine, Binoy Joseph D. 

J Vis Exp. 2026 Jun 12;(232). doi: 10.3791/70973. PMID: 42517431.

Single cell map of the adult female mouse urethra reveals epithelial and stromal macrophages with distinct functional identities

Jasmine, Samtiya M, Rodrigues R, Mandal A, Kavya TT, Anushree A, Lafin JT, Vezina CM, Strand DW, Binoy Joseph D.

Mucosal Immunol. 2025 Dec;18(6):1325-1340. PMID: 40907791

Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns

Jasmine, Baraiya DH, Kavya TT, Mandal A, Chakraborty S, Sathish N, Francis CMR, Binoy Joseph D.

Dev Biol. 2025 Apr;520:155-170. PMID: 39798644

Male Reproductive Tract: Development Overview

Binoy Joseph D and Vezina CM.

Encyclopedia of Reproduction, 3e, vol. 1, pp. 343–352.

Skinner, Michael K. (ed.), Elseveir 2026

Collaborative Publications

2026

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Awais Ullah Ihsan, Mozhdeh Namvarpour, Mohammad Moradzad, Anny Armas Cayarga, Evelyne Ng Kwan Lim, Diya Binoy Joseph, Stephanie Petkiwicz, Eric Massé, Akihiko Yoshimura, Gerardo Ferbeyre, Alfredo Menendez, Sheela Ramanathan, Subburaj Ilangumaran. SOCS1 expression in prostate epithelial cells is essential for tissue homeostasis and tumor suppression. bioRxiv, 2026.05. 09.723770

Diya Binoy Joseph’s Postdoctoral and PhD publications

2024

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Caden M. Ulschmid, Miranda R. Sun, Christopher R. Jabbarpour,….Ligia A. Papale, Diya B. Joseph, Chad M. Vezina, Reid S. Alisch, and Robert J. Lipinski. ‘Disruption of DNA methylation–mediated cranial neural crest proliferation and differentiation causes orofacial clefts in mice.’ Proc Natl Acad Sci U S A. (2024); 121(3):e2317668121 PMID: 38194455 

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2022

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Diya B. Joseph, Gervaise H. Henry, Alicia Malewska, Jeffrey C. Reese, Ryan J. Mauck, Jeffrey C. Gahan, Ryan C. Hutchinson, James L. Mohler, Claus G. Roehrborn, Douglas W. Strand. ‘5-alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia.’ Journal of Pathology (2022); 256(4), 427-441 PMID: 34928497 

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​2021

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Diya B. Joseph, Gervaise H. Henry, Alicia Malewska, Jeffrey C. Reese, Ryan J. Mauck, Jeffrey C. Gahan, Ryan C. Hutchinson, Venkat S. Malladi, Claus G. Roehrborn, Chad M. Vezina, Douglas W. Strand. ‘Single cell analysis of mouse and human prostate reveals novel fibroblasts with specialized distribution and microenvironment interactions.’ Journal of Pathology (2021); 255(2), 141-154  PMID: 34173975 

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Anne E. Turco, Steven R. Oakes, Kimberly P. Keil Stietz, Cheryl L. Dunham, Diya B. Joseph, Thrishna S. Chathurvedula, Nicholas M. Girardi, Andrew J. Schneider, Joseph Gawdzik, Celeste M. Sheftel, Peiqing Wang, Zunyi Wang, Dale E Bjorling, William A. Ricke, Weiping Tang, Laura L. Hernandez, Janet R. Keast, Adrian D. Bonev, Matthew D. Grimes, Douglas W. Strand, Nathan R. Tykocki, Robyn L. Tanguay, Richard E. Peterson, Chad M. Vezina. ‘A mechanism linking perinatal 2,3,7,8 tetrachlorodibenzo-p-dioxin exposure to lower urinary tract dysfunction in adulthood.’ Dis Model Mech (2021); 14(7):dmm049068 PMID: 34318329

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Diya B. Joseph, Anne E. Turco, Chad M. Vezina, Douglas W. Strand. ‘Progenitors in prostate development and disease.’ Developmental Biology (2021); 473, 50-58 PMID: 33529704 

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2020


Diya B. Joseph, Gervaise H. Henry, Alicia Malewska, Nida S. Iqbal, Hannah M. Ruetten, Anne E. Turco, Lisa L. Abler, Simran K. Sand’hu, Mark T. Cadena, Venkat S. Malladi, Jeffrey C. Reese, Ryan J. Mauck, Jeffrey C. Gahan, Ryan C. Hutchinson, Claus G. Roehrborn, Linda A. Baker, Chad M. Vezina, Douglas W. Strand. ‘Urethral luminal epithelia are castration-insensitive cells of the proximal prostate.’ Prostate (2020); 80, 872-884  PMID: 32497356


Su-Tang Lo, Daniel Parrott, M. Veronica Clavijo Jordan, Diya B. Joseph, Douglas Strand, U-Ging Lo, Ho Lin, Anza Darehshouri, A. Dean Sherry. ‘The roles of ZnT1 and ZnT4 in glucose-stimulated zinc secretion in prostate epithelial cells.’ Molecular Imaging and Biology (2020); 23, 230-240   PMID: 33140261

 

2018


Diya B. Joseph, Anoop S. Chandrashekar, Lisa L. Abler, Li-Fang Chu, James A. Thomson, Cathy Mendelsohn, and Chad M. Vezina. ‘In vivo replacement of damaged bladder urothelium by Wolffian duct epithelial cells.’ PNAS (2018); 115, 8394-8399 PMID: 30061411


Diya B. Joseph, Anoop S. Chandrashekar, Li-Fang Chu, James A. Thomson and Chad M. Vezina. ‘A folic acid-enriched diet attenuates prostate involution in response to androgen deprivation.’ Prostate (2018) ;79, 183-194  PMID: 30298636


Diya B. Joseph, Anoop S. Chandrashekar, Lisa L. Abler, Li-Fang Chu, James A. Thomson and Chad M. Vezina. ‘Epithelial DNA methyltransferase-1 regulates cell survival, growth and maturation in developing prostate buds.’ Developmental Biology (2019); 447, 157-169  PMID: 30659795 


Diya B. Joseph and Chad M. Vezina. ‘Male Reproductive Tract: Development Overview’ Encyclopedia of Reproduction 2nd edition, vol. 1, pp. 248–255, Elsevier 2018  (Book Chapter)


Diya B. Joseph, Douglas W. Strand and Chad M. Vezina. ‘DNA methylation in development and disease: An overview for prostate researchers.’ Am J Clin Exp Urol (2018); 6(6),197-218  PMID: 30697577


Gervaise H. Henry, Alicia Malewska, Diya B. Joseph, Venkat S. Malladi, Jeon Lee, Jose Torrealba, Ryan J. Mauck, Jeffrey C. Gahan, Claus G. Roehrborn, Gary C. Hon, Jeffrey C. Reese, Ryan C. Hutchinson, Chad M. Vezina, Douglas W. Strand. ‘A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra’ Cell Reports (2018); 25, 3530–3542 PMID: 30566875

 

2013


Sinoy S, Diya Binoy Joseph, Rajanikant GK.  ‘Evolving Therapeutic Targets in Ischemic stroke: A Concise Review.’ Current Drug Targets (2013); 14(4), 497-506  PMID: 23278314 

 

2012


Pradeep H, Diya Joseph, Shashikumar S, Rajanikant GK. ‘Oxidative Stress: Assassin behind the Ischemic Stroke’. Folia Neuropathol (2012); 50(3),219-30  PMID: 23023336

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